期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 39, 期 1, 页码 215-222出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201808014
关键词
aryl bromide; bromodifluoromethane; difluoromethylation; nickel; reductive cross-coupling
资金
- National Basic Research Program of China (973 Program) [2015CB931900]
- National Natural Science Foundation of China [21425208, 21672238, 21332010, 21421002]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
A nickel-catalyzed direct difluoromethylation of (hetero)aryl bromides with bromodifluoromethane (BrCF2H) is described. This reaction features high efficiency, broad substrate scope and high functional group tolerance, providing a cost-efficient and straightforward route for applications in medicinal chemistry. Preliminary mechanistic studies reveal that a nickel-based, reductive cross-coupling catalytic cycle is involved in the reaction.
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