期刊
MOLECULAR CELL
卷 65, 期 6, 页码 965-973出版社
CELL PRESS
DOI: 10.1016/j.molcel.2017.02.024
关键词
-
资金
- Science Foundation Ireland [14/IA/ 2622]
- Worldwide Cancer Research [14-0323]
- Science Foundation Ireland (SFI) [14/IA/2622] Funding Source: Science Foundation Ireland (SFI)
Necroptosis (programmed necrosis) occurs in response to TNF, Fas, or TRAIL, as well as certain TLR ligands, when caspase activity required for apoptosis is blocked. Necroptosis is typically considered a highly pro-inflammatory mode of cell death, due to release of intracellular danger signals'' that promote inflammation. However, because most pro-necroptotic stimuli are intrinsically highly pro-inflammatory-due to their ability to initiate the synthesis of numerous cytokines and chemokines-the inflammatory consequences of necroptosis are complex. Here, we suggest that necroptosis might have anti-inflammatory effects in certain settings, through curbing excessive TNF- or TLR-induced inflammatory cytokine production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据