期刊
MOLECULAR CELL
卷 65, 期 5, 页码 777-778出版社
CELL PRESS
DOI: 10.1016/j.molcel.2017.02.012
关键词
-
资金
- NIGMS NIH HHS [R01 GM104135] Funding Source: Medline
In this issue of Molecular Cell, Bonfiglio et al. (2017) demonstrate that histone PARylation factor 1 (HPF1) is required for PARP1 to attach ADP-ribose groups onto the hydroxyl oxygen of the Ser residues of target substrates, including both PARP1 itself and histones. Here, mechanisms and implications of this unexpected, O-linked ADP-ribosylation are speculated on.
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