Application of Molecularly Imprinted Biomembrane for Advancement of Matrix Solid-Phase Dispersion for Clean Enrichment of Parabens from Powder Sunscreen Samples: Optimization of Chromatographic Conditions and Green Approach

In this research work, molecularly imprinted biomembranes (MI-BMs) were fabricated by using the natural substance as a multifunctional monomer and methyl paraben as the template in a one-pot and green condition. Subsequently, the application of resulting MI-BMs as a dispersant sorbent in matrix solid-phase dispersion (MSPD) was evaluated, which exhibited supreme performance for cleanup and isolation of paraben's family from complicated matrices. More importantly, the chromatographic conditions that affect resolution, band spreading, and peak symmetry were studied and optimized. Also, the effects of individual parameters and their significant interactions on extraction efficiency were concurrently optimized by a multivariate optimization methodology. Under an optimized condition, the developed MI-BM-MSPD method exhibited wide linear ranges of 40.0-10 000.0, 40.0-10 000.0, and 50.0-10 000.0 mu g kg(-1) with satisfactory recoveries ranging from 92.5 to 102.5, 88.8 to 101.5, and 92.0 to 102.8%, for methylparaben, ethylparaben, and propylparaben, respectively. Low detection limits close to 11.1 mu g kg(-1) and excellent repeatability (relative standard deviation <= 4.6%) imply that an innovative MI-BM-MSPD approach is qualified for simultaneous quantitative detection of parabens in complex samples along with simplicity in the line of green and sustainable chemistry.