期刊
MOLECULAR CARCINOGENESIS
卷 56, 期 12, 页码 2681-2691出版社
WILEY
DOI: 10.1002/mc.22711
关键词
amino acid response; autophagy; caloric restriction; chemotherapy; ovarian cancer
资金
- Ministry of Education, University and Research (MIUR
- Italy)
- Di Lauro-Isidoro Maria pre-doctoral fellowship by the Associazione per la Ricerca Medica Ippocrate-Rhazi (Novara, Italy)
- Di Lauro Liberato post-doctoral fellowship by the Associazione per la Ricerca Medica Ippocrate-Rhazi (Novara, Italy)
- Comoli, Ferrari & Co (Novara, Italy)
The potential benefit of nutrient starvation in the prevention and treatment of cancer is presently under consideration. Resveratrol (RV), a dietary polyphenol acting as a protein (caloric) restriction mimetic, could substitute for amino acid starvation. The effects of starvation and of caloric restriction are mediated, among others, by autophagy, a process that contributes to cell homeostasis by promoting the lysosomal degradation of damaged and redundant self-constituents. Up-regulation of autophagy favors cell survival under nutrient shortage situation, and may drive cancer cells into a non-replicative, dormant state. Both RV and amino acid starvation effectively induced the aminoacid response and autophagy. These processes were associated with inhibition of the mTOR pathway and disruption of the BECLIN1-BCL-2 complex. The number of transcripts positively impinging on the autophagy pathway was higher in RV-treated than in starved cancer cells. Consistent with our data, it appears that RV treatment is more effective than and can substitute for starvation for inducing autophagy in cancer cells. The present findings are clinically relevant because of the potential therapeutic implications.
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