期刊
MOLECULAR CARCINOGENESIS
卷 56, 期 9, 页码 2158-2164出版社
WILEY
DOI: 10.1002/mc.22667
关键词
pancreatic cancer; population based case-control study; s-MICA
资金
- National Center for Advancing Translational Sciences [UL1 TR000114]
- National Cancer Institute [R25CA163184]
- American Cancer Society [124166-IRG-58-001-55]
Pancreatic cancer is diagnosed at a late stage and has one of the highest cancer mortality rates in the United States, creating an urgent need for novel early detection tools. A candidate biomarker for use in early detection is the soluble MHC class I-related chain A (s-MICA) ligand, which pancreatic tumors shed to escape immune detection. The objective of this study was to define the association between s-MICA levels and pancreatic cancer, in a population-based case-control study. S-MICA was measured in 143 pancreatic cancer cases and 459 controls. Unconditional logistic regression was used to calculate odds ratio (OR) for pancreatic cancer and 95% confidence intervals (CI). There was a positive association between increasing s-MICA levels and pancreatic cancer: compared to the lowest tertile, the ORs for pancreatic cancer were 1.25 (95%CI: 0.75-2.07) and 2.10 (95%CI: 1.29-3.42) in the second and highest tertiles, respectively (P-trend=0.02). Our study supports previous work demonstrating a positive association between plasma s-MICA levels and pancreatic cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据