期刊
MOLECULAR CANCER THERAPEUTICS
卷 16, 期 12, 页码 2803-2816出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1535-7163.MCT-17-0339
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资金
- National Research Foundation (NRF) - Korea government [2014R1A5A2009242, 2012M2A2A7035589]
- Institute for Basic Science (IBS), Republic of Korea [IBS-R005-G1]
- National Research Foundation of Korea [2014R1A5A2009242, 2012M2A2A7035589] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Cellular cross-talk between tumors and M2-polarized tumor-associated macrophages (TAM) favors tumor progression. Upregulation of IL4 receptor (IL4R) is observed in diverse tumors and TAMs. We tested whether an IL4R-targeted proapoptotic peptide could inhibit tumor progression. The IL4R-binding peptide (IL4RPep-1) preferentially bound to IL4R-expressing tumor cells and M2-polarized macrophages both in vitro and in 4T1 breast tumors in vivo. To selectively kill IL4R-expressing cells, we designed an IL4R-targeted proapoptotic peptide, IL4RPep-1-K, by adding the proapoptotic peptide (KLAKLAK)(2) to the end of IL4RPep-1. IL4RPep-1-K exerted selective cytotoxicity against diverse IL4-Rexpressing tumor cells and M2-polarized macrophages. Systemic administration of IL4RPep-1-K inhibited tumor growth and metastasis in 4T1 breast tumor-bearing mice. Interestingly, IL4RPep-1-K treatment increased the number of activated cytotoxic CD8(+) T cells while reducing the numbers of immunosuppressive regulatory T cells and M2-polarized TAMs. No significant systemic side effects were observed. These results suggest that IL4R-targeted proapoptotic peptide has potential for treating diverse IL4-Rexpressing cancers. (C) 2017 AACR.
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