期刊
MOLECULAR CANCER
卷 16, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12943-017-0612-0
关键词
Long non-coding RNAs (lncRNAs); The SWI/SNF complexes; Chromatin remodeling; Gene expression; Carcinogenesis
资金
- National Natural Science Foundation of China [81372907, 81301757, 81472531, 81402009, 81572787, 81672683]
- Natural Science Foundation of Hunan Province [14JJ1010, 2015JJ1022]
- Mittal Innovation Foundation of Central South University [MX2016442, 15MX46]
- Fundamental Research Funds for Central Universities of Central South University [2016zzts478]
Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports have shown that long non-coding RNAs (lncRNAs) are tightly associated with chromatin remodeling. In this review, we focused on important chromatin remodelers called the switching defective/sucrose nonfermenting (SWI/SNF) complexes, which use the energy of ATP hydrolysis to control gene transcription by altering chromatin structure. We summarize a link between lncRNAs and the SWI/SNF complexes and their role in chromatin remodeling and gene expression regulation in cancer, thereby providing systematic information and a better understanding of carcinogenesis.
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