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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest Oncology Group study (S0336)
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INVESTIGATIONAL NEW DRUGS (2009)
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
Patrick Trojer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Lack of Therapeutic Effect of the Histone Deacetylase Inhibitor Vorinostat in Patients with Metastatic Radioiodine-Refractory Thyroid Carcinoma
Jennifer A. Woyach et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)
Histone Deacetylase Inhibitors in Cancer Therapy
Andrew A. Lane et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study
Evanthia Galanis et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma
Richard L. Piekarz et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Vorinostat (NSC# 701852) in Patients with Relapsed Non-small Cell Lung Cancer A Wisconsin Oncology Network Phase II Study
Anne M. Traynor et al.
JOURNAL OF THORACIC ONCOLOGY (2009)
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
Tina Branscombe Miranda et al.
MOLECULAR CANCER THERAPEUTICS (2009)
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
Ann-Marie Broeske et al.
NATURE GENETICS (2009)
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim et al.
NATURE MEDICINE (2009)
Protein methyltransferases as a target class for drug discovery
Robert A. Copeland et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
DACT3 is an epigenetic regulator of Wnt/β-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
Xia Jiang et al.
CANCER CELL (2008)
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
Andrei V. Krivtsov et al.
CANCER CELL (2008)
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
Ulrich Schueller et al.
CANCER CELL (2008)
Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells
Zeng-Jie Yang et al.
CANCER CELL (2008)
Identification and characterization of ovarian cancer-initiating cells from primary human tumors
Shu Zhang et al.
CANCER RESEARCH (2008)
The epithelial-mesenchymal transition generates cells with properties of stem cells
Sendurai A. Mani et al.
CELL (2008)
The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
Elizabeth Vincan et al.
CLINICAL & EXPERIMENTAL METASTASIS (2008)
Clinical and molecular responses in lung cancer patients receiving Romidepsin
David S. Schrump et al.
CLINICAL CANCER RESEARCH (2008)
A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study
Thehang H. Luu et al.
CLINICAL CANCER RESEARCH (2008)
Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
Jing Yang et al.
DEVELOPMENTAL CELL (2008)
Epigenetic gene silencing in the Wnt pathway in breast cancer
George J. Klarmann et al.
EPIGENETICS (2008)
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
Sun-Mi Park et al.
GENES & DEVELOPMENT (2008)
A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study
Susan C. Modesitt et al.
GYNECOLOGIC ONCOLOGY (2008)
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
Carlo Stresemann et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
Johan Vansteenkiste et al.
INVESTIGATIONAL NEW DRUGS (2008)
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
Manav Korpal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
David J. Steger et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Polycomb complex 2 is required for E-cadherin repression by the snail1 transcription factor
Nicolas Herranz et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells
Kenneth K. W. To et al.
MOLECULAR CANCER RESEARCH (2008)
Roles of the EZH2 histone methyltransferase in cancer epigenetics
Jeffrey A. Simon et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2008)
Identification of cells initiating human melanomas
Tobias Schatton et al.
NATURE (2008)
Efficient tumour formation by single human melanoma cells
Elsa Quintana et al.
NATURE (2008)
The mir-200 family and mir-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
Philip A. Gregory et al.
NATURE CELL BIOLOGY (2008)
Combinatorial patterns of histone acetylations and methylations in the human genome
Zhibin Wang et al.
NATURE GENETICS (2008)
Repression of E-cadherin by the polycomb group protein EZH2 in cancer
Q. Cao et al.
ONCOGENE (2008)
Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells
Yutaka Kondo et al.
PLOS ONE (2008)
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
Anne-Pierre Morel et al.
PLOS ONE (2008)
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
Nancy Dumont et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Identification and expansion of the tumorigenic lung cancer stem cell population
A. Eramo et al.
CELL DEATH AND DIFFERENTIATION (2008)
Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza™, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer
George R. Blumenschein et al.
INVESTIGATIONAL NEW DRUGS (2008)
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
Dorothee Mueller et al.
BLOOD (2007)
Development and characterization of gemcitabine-resistant pancreatic tumor cells
Ami N. Shah et al.
ANNALS OF SURGICAL ONCOLOGY (2007)
Covalent modifications of histones during development and disease pathogenesis
Sukesh R. Bhaumik et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas
Yutaka Kondo et al.
HEPATOLOGY RESEARCH (2007)
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination
Min Gyu Lee et al.
SCIENCE (2007)
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development
Karl Agger et al.
NATURE (2007)
A histone H3 lysine 27 demethylase regulates animal posterior development
Fei Lan et al.
NATURE (2007)
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
Kim Appleton et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
LSD1 and the chemistry of histone demethylation
Jeffrey C. Culhane et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2007)
Down-regulation of HILA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition
Hiroshi Kitamura et al.
JOURNAL OF UROLOGY (2007)
Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
Elise A. Olsen et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
PTIP associates with MLL3-and MLL4-containing histone H3 lysine 4 methyltransferase complex
Young-Wook Cho et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition
Samudra K. Dissanayake et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Identification and characterization of tumorigenic liver cancer stem/progenitor cells
Stephanie Ma et al.
GASTROENTEROLOGY (2007)
Stability and flexibility of epigenetic gene regulation in mammalian development
Wolf Reik
NATURE (2007)
Pharmacologic disruption of polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
Jing Tan et al.
GENES & DEVELOPMENT (2007)
CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
Dagmar Beier et al.
CANCER RESEARCH (2007)
Epigenetic gene silencing in cancer: the DNA hypermethylome
Manel Esteller
HUMAN MOLECULAR GENETICS (2007)
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
Irina Issaeva et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Chromatin modifications and their function
Tony Kouzarides
CELL (2007)
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
Stefan Kubicek et al.
MOLECULAR CELL (2007)
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
Joyce E. Ohm et al.
NATURE GENETICS (2007)
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani et al.
NATURE (2007)
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
Emmanuelle Bitoun et al.
HUMAN MOLECULAR GENETICS (2007)
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
Eli E. Bar et al.
STEM CELLS (2007)
Wnt signalingg stem cells and the cellular origin of breast cancer
Charlotta Lindvall et al.
STEM CELL REVIEWS (2007)
Up-regulation of HLA class-I antigen expression and antigen-specific CTL response in cervical cancer cells by the demethylating agent hydralazine and the histone deacetylase inhibitor valproic acid
Maria de Lourdes Mora-Garcia et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2006)
Mining the Wnt pathway for cancer therapeutics
Nick Barker et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Angiogenesis-independent tumor growth mediated by stem-like cancer cells
Per O. Sakariassen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
Notch signalling regulates stem cell numbers in vitro and in vivo
Andreas Androutsellis-Theotokis et al.
NATURE (2006)
Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCα in an aldosterone-sensitive manner
Wenzheng Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A phase II study of depsipeptide in refractory metastatic renal cell cancer
Walter M. Stadler et al.
CLINICAL GENITOURINARY CANCER (2006)
Cyclooxygenase-2-dependent regulation of E-cadherin:: Prostaglandin E2 induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
Mariam Dohadwala et al.
CANCER RESEARCH (2006)
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
AP Bracken et al.
GENES & DEVELOPMENT (2006)
Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions
LH Wang et al.
MODERN PATHOLOGY (2006)
JmjC-domain-containing proteins and histone demethylation
Robert J. Klose et al.
NATURE REVIEWS GENETICS (2006)
Prospective identification of tumorigenic prostate cancer stem cells
AT Collins et al.
CANCER RESEARCH (2005)
5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
K Ghoshal et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
hDOT1L links histone methylation to leukemogenesis
Y Okada et al.
CELL (2005)
Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy
C Blank et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2005)
FDA drug approval summary:: Azacitidine (5-azacytidine, Vidaza™) for injectable suspension
E Kaminskas et al.
ONCOLOGIST (2005)
Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas
H Duan et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
H Suzuki et al.
NATURE GENETICS (2004)
RENKCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma
L Di Marcotullio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Tissue repair and stem cell renewal in carcinogenesis
PA Beachy et al.
NATURE (2004)
Identification of human brain tumour initiating cells
SK Singh et al.
NATURE (2004)
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
CG Kleer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
RW Johnstone et al.
CANCER CELL (2003)
Prospective identification of tumorigenic breast cancer cells
M Al-Hajj et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Histone deacetylases (HDACs): characterization of the classical HDAC family
AJM De Ruijter et al.
BIOCHEMICAL JOURNAL (2003)
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein
A Kuzmichev et al.
GENES & DEVELOPMENT (2002)
Role of histone H3 lysine 27 methylation in polycomb-group silencing
R Cao et al.
SCIENCE (2002)
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells
S Koizume et al.
NUCLEIC ACIDS RESEARCH (2002)
Histone methyltransferase activity of a Drosophila polycomb group repressor complex
J Müller et al.
CELL (2002)
The polycomb group protein EZH2 is involved in progression of prostate cancer
S Varambally et al.
NATURE (2002)
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis
M Tachibana et al.
GENES & DEVELOPMENT (2002)
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
M Göttlicher et al.
EMBO JOURNAL (2001)
Hedgehog signaling in animal development: paradigms and principles
PW Ingham et al.
GENES & DEVELOPMENT (2001)
Stem cells, cancer, and cancer stem cells
T Reya et al.
NATURE (2001)
Role of protein methylation in chromatin remodeling and transcriptional regulation
MR Stallcup
ONCOGENE (2001)
Activation of MHC class I, II, and CD40 gene expression by histone deacetylase inhibitors
WJ Magner et al.
JOURNAL OF IMMUNOLOGY (2000)
Deacetylation of p53 modulates its effect on cell growth and apoptosis
JY Luo et al.
NATURE (2000)