期刊
MOLECULAR BIOLOGY OF THE CELL
卷 28, 期 10, 页码 1337-1346出版社
AMER SOC CELL BIOLOGY
DOI: 10.1091/mbc.E16-06-0381
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资金
- Department of Defense Ovarian Cancer Research Program [OC093424]
- Randy Shaver Cancer Research Funds
- CDMRP [546101, OC093424] Funding Source: Federal RePORTER
UNC-45A is a highly conserved member of the UNC-45/CRO1/She4p family of proteins, which act as chaperones for conventional and nonconventional myosins. NMII mediates contractility and actin-based motility, which are fundamental for proper growth cone motility and neurite extension. The presence and role of UNC-45A in neuronal differentiation have been largely unknown. Here we demonstrate that UNC-45A is a novel growth cone-localized, NMII-associated component of the multiprotein complex regulating growth cone dynamics. We show that UNC-45A is dispensable for neuron survival but required for neurite elongation. Mechanistically, loss of UNC-45A results in increased levels of NMII activation. Collectively our results provide novel insights into the molecular mechanisms of neurite growth and define UNC-45A as a novel and master regulator of NMII-mediated cellular processes in neurons.
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