期刊
MOLECULAR ASPECTS OF MEDICINE
卷 56, 期 -, 页码 90-100出版社
ELSEVIER
DOI: 10.1016/j.mam.2017.05.003
关键词
Bile acids; Pregnancy; Fetus; Placenta; Metabolism; Intrahepatic cholestasis of pregnancy
资金
- Guy's and St Thomas' Charity
- Wellcome Trust [P30874]
- Tommy's Charity
- ICP Support
- National Institute of Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust
- Austrian Science Fund (FWF) [P30874] Funding Source: Austrian Science Fund (FWF)
There are numerous profound maternal physiological changes that occur from conception onwards and adapt throughout gestation in order to support a healthy pregnancy. By the time of late gestation, when circulating pregnancy hormones are at their highest concentrations, maternal adaptations include relative hyperlipidemia, hypercholanemia and insulin resistance. Bile acids have now been established as key regulators of metabolism, and their role in gestational changes in metabolism is becoming apparent. Bile acid homeostasis is tightly regulated by the nuclear receptor FXR, which has been shown to have reduced activity during pregnancy. This review focuses on the gestational alterations in bile acid homeostasis that occur in normal pregnancy, which in some women can become pathological, leading to the development of intrahepatic cholestasis of pregnancy. As well as their important role in maternal metabolic health, we will review bile acid metabolism in the feto- placental unit. (C) 2017 Elsevier Ltd. All rights reserved.
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