期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 458, 期 C, 页码 91-104出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.04.006
关键词
Deiodinases; Enzyme mimetics; Inhibitors; Selenium; Thyromimetics; Thyroid homones
资金
- Science and Engineering Research Board (SERB), India
- Indian Institute of Science, Bangalore
- SERB [SB/S2/JCB-067/2015]
Thyroid hormones (THs) play key roles in modulating the overall metabolism of the body, protein synthesis, fat metabolism, neuronal and bone growth, and cardiovascular as well as renal functions. In this review, we discuss on the thyroid hormone synthesis and activation, thyroid hormone receptors (TRs) and mechanism of action, applications of thyroid hormone analogues, particularly the compounds that are selective ligands for TR beta receptors, or enzyme inhibitors for the treatment of thyroidal disorders with a specific focus on thyroid peroxidase and iodothyronine deiodinases. We also discuss on the development of small-molecule deiodinase mimetics and their mechanism of deiodination, as these compounds have the potential to regulate the thyroid hormone levels. (C) 2017 Elsevier B.V. All rights reserved.
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