期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 455, 期 C, 页码 4-12出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2017.01.042
关键词
Immunosenescence; Autoimmune diseases; Metabolism; Aging; Fasting; Fasting mimicking diet
资金
- NIA NIH HHS [R01 AG052558] Funding Source: Medline
Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence. (C) 2017 Elsevier B.V. All rights reserved.
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