期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 442, 期 C, 页码 98-105出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.12.013
关键词
Phytosteroid; Herbal supplement; Progestin; Androgen; Corticoid
资金
- National Institutes of Health (NIH)
- National Center for Complementary and Integrative Health (NCCIH) [R01 AT008824-01A1]
- T32 fellowship [T32AT007533]
Foods and botanical supplements can interfere with the endocrine system through the presence of phytosteroids - chemicals that interact with steroids receptors. Phytoestrogens are well studied, but compounds such as kaempferol, apigenin, genistein, ginsenoside Rf, and glycyrrhetinic acid have been shown to interact with non-estrogen nuclear receptors. These compounds can have agonist, antagonist, or mixed agonist/antagonist activity depending on compound, receptor, cell line or tissue, and concentration. Some phytosteroids have also been shown to inhibit steroid metabolizing enzymes, resulting in biological effects through altered endogenous steroid concentrations. An interesting example, compound A (4[1-chloro-2-(methylamino)ethyl]phenyl acetate hydrochloride (1:1)) is a promising selective glucocorticoid receptor modulator (SGRM) based on a phytosteroid isolated from Salsola tuberculatiformis Botschantzev. Given that $6.9 billion of herbal supplements are sold each year, is clear that further identification and characterization of phytosteroids is needed to ensure the safe and effective use of botanical supplements. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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