期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 449, 期 C, 页码 42-55出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2016.08.022
关键词
GnRH; GPCR; NFAT; ERK; Mathematical modeling; Mutual information
资金
- MRC [93447]
- BBSRC [J014699]
- EPSRC [EP/N014391/1]
- MRC Biomedical Informatics Fellowship [MR/K021826/1]
- BBSRC [BB/J014699/1] Funding Source: UKRI
- EPSRC [EP/N014391/1] Funding Source: UKRI
- MRC [G0901763, MR/K021826/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J014699/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/N014391/1] Funding Source: researchfish
- Medical Research Council [MR/K021826/1, G0901763] Funding Source: researchfish
Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
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