期刊
CHEMICAL SCIENCE
卷 10, 期 4, 页码 1193-1200出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc04464c
关键词
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资金
- Beijing Talent Foundation Outstanding Young Individual Project [2015000026833ZK02]
- Beijing Municipal Natural Science Foundation [KZ201810028045]
- Beijing Municipal Education Commission [KZ201810028045]
- Capacity Building for Sci-Tech Innovation-Fundamental Scientific Research Funds [025185305000/195]
- Project of High-level Teachers in Beijing Municipal Universities in the Period of the 13th Five-year Plan [IDHT20180517]
- Project of Construction of Scientific Research Base by the Beijing Municipal Education Commission
- Yanjing Young Scholar Development Program of Capital Normal University
- Youth Innovative Research Team of Capital Normal University
Lung injury is a hydrogen sulfide (H2S)-associated complication with high mortality in acute pancreatitis (AP) cases. Herein, we used Prussian Blue (PB) as a H2S-responsive acceptor to develop a novel pure-inorganic upconversion nanoprobe for detecting and eliminating H2S, which can be used for diagnosing AP and alleviating lung injury. Upconversion nanoprobes with 5 nm PB shells were optimized to achieve outstanding in vitro H2S detection capacity (linear range: 0-150 mu M, LOD: 50 nM), which met the in vivo serum H2S range, and thus were feasible for imaging H2S in vivo. More importantly, when combined with the traditional H2S synthetase inhibitor DL-PAG, the nanoprobes also served as a therapeutic agent that synergistically alleviated lung injury. As PB is an FDA-approved drug, our work proposes a potential clinical modality for the early diagnosis of AP, which will decrease lung injury-induced mortality and increase the survival rates of AP cases.
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