期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 4, 页码 876-884出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob03061h
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资金
- Engineering Technology Research Center for Grain & Oil Food, State Administration of Grain [GA2018004]
A novel and convenient palladium-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with acetonitrile was developed to synthesize 3-amidated quinoxalin-2(1H)-ones. A series of 3-acetamino quinoxalin-2(1H)-one derivatives were constructed with good to excellent yields. This methodology provided a practical approach to various 3-acetamino quinoxalin-2(1H)-ones from the readily available starting material acetonitrile.
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