期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 6, 页码 866-869出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc09456j
关键词
-
资金
- National Natural Science Foundation of China [21471033, 51672046, 51472050, 21603033]
We designed and synthesized a simple, but highly effective photo-sensitizer (G-Mito-Pc), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity of G-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.
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