Enzyme-like substrate-selectivity in C-H oxidation enabled by recognition

Substrate-selectivity stemming from recognition is a key feature of enzymes that has been seldom observed in artificial catalysts. Herein, we report a recognition-driven, substrate-selective C-H oxidation that inverts the intrinsic reactivity of the competing C-H bonds. Analysis of this selectivity highlights an unexpectedly high reactivity enhancement imparted by intramolecularity.