Metal coordination-functionalized Au-Ag bimetal SERS nanoprobe for sensitive detection of glutathione

We demonstrated a surface-enhanced Raman spectroscopy (SERS) nanoprobe, neocuproine-Cu (Nc-Cu-III)-functionalized Au-Ag nanobowls (Au-Ag NBs/Nc-Cu-II), for detection of glutathione (GSH). Detection was accomplished with alternation of SERS spectra from Nc-Cu-II into Nc-Cu-I resulting from the reaction of GSH with Nc-Cu-II on Au-Ag NBs. This nanoprobe exhibited high selectivity and sensitivity (mu M) towards GSH.