期刊
JOURNAL OF CANCER
卷 10, 期 4, 页码 927-936出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.27160
关键词
Cancer; MTA; Metabolism; MTAP; Polyamine
类别
资金
- National Natural Science Foundation of China [81272313]
While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a century ago, altered metabolism has recently returned as a focus of cancer research. 5'-Methylthioadenosine (MTA) is a naturally occurring sulfur-containing nucleoside found in numerous species. While MTA was first isolated several decades ago, a lack of sensitive and specific analytical methodologies designed for its direct quantification has hampered the study of its physiological and pathophysiological features. Many studies indicate that MTA suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. In this review, we assessed the effects of MTA and of related materials on the growth and functions of normal and malignant cells.
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