期刊
MITOCHONDRION
卷 44, 期 -, 页码 15-19出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2017.12.006
关键词
Chronic progressive external ophthalmoplegia; Mitochondria; Strength; Smoking; Phenotypic spectrum
Chronic progressive external ophthalmoplegia (CPEO) is a common mitochondrial disease. We evaluated the impact of sex and smoking status upon knee extension strength and the phenotypic spectrum of disease in a large cohort of adult-onset CPEO patients (N = 116) using retrospective chart analysis. The CPEO patients showed significantly lower knee extension strength as compared to the age- and sex-matched control population (-37%, P < 0.05). Smoking also negatively impacted knee extension strength only in women with CPEO (-26%, P < 0.05). We conclude that smoking and female sex interact negatively in CPEO patients.
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