期刊
PHYSIOLOGICAL REPORTS
卷 7, 期 2, 页码 -出版社
WILEY
DOI: 10.14814/phy2.13988
关键词
Blood pressure; femoral blood flow; microneurography; sex differences; sympathetic nervous system; vascular resistance
类别
资金
- American Heart Association [15PRE24470033]
- William R. Hikes Memorial Endowment for Heart Research
- NIH from the National Center for Advancing Translational Sciences (NCATS) [UL1 TR002014, KL2 TR002015]
- Pennsylvania Department of Health
Emerging evidence suggests that sympathetic vasoconstriction is lower in young women. We hypothesized that increases in muscle sympathetic nerve activity (MSNA) during acute physiological stressors induce less vasoconstriction in young women compared to young men. Healthy young men (n = 10, 27 +/- 1 years), young women (n = 12, 25 +/- 1 years), and older women (n = 10, 63 +/- 6 years) performed the cold pressor test (hand in ice for 2 min) and continuous hypoxia (10% O-2, 90% N-2) for 5 min. MSNA, femoral blood flow velocity, heart rate, and blood pressure were acquired continuously. Femoral artery diameter was obtained every minute and used to calculate femoral blood flow, and femoral vascular resistance and conductance. MSNA responses to cold pressor test (P = 0.345) and hypoxia (P = 0.969) were not different between groups. Young women had greater femoral blood flow (P = 0.002) and vascular conductance (P = 0.041) responses to cold pressor test compared with young men. The femoral blood flow response to hypoxia was not different between the two sexes but the increase in femoral flow was attenuated in older women compared with younger women (P = 0.036). These data show that young women had paradoxical vasodilation to cold pressor test. The mechanisms responsible for the attenuated sympathetic vasoconstriction or for enhanced vasodilation in young women during the CPT require further investigation.
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