期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 17, 期 6, 页码 529-540出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557516666160923132611
关键词
Biotin toxicity; biotin; gene expression; guanylate cyclase; histone biotinylation; pharmacological effects
资金
- CONACyT from Fondos Federales [219787, 074/2013]
- Direccion General de Asuntos del Personal Academico Universidad Nacional Autonoma de Mexico [IN 210714]
In recent decades, it was found that vitamins affect biological functions in ways other than their long-known functions; niacin is the best example of a water-soluble vitamin known to possess multiple actions. Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin that serves as a covalently-bound coenzyme of carboxylases. It is now well documented that biotin has actions other than participating in classical enzyme catalysis reactions. Several lines of evidence have demonstrated that pharmacological concentrations of biotin affect glucose and lipid metabolism, hypertension, reproduction, development, and immunity. The effect of biotin on these functions is related to its actions at the transcriptional, translational, and post-translational levels. The best-supported mechanism involved in the genetic effects of biotin is the soluble guanylate cyclase/protein kinase G (PKG) signaling cascade. Although there are commercially-available products containing pharmacological concentrations of biotin, the toxic effects of biotin have been poorly studied. This review summarizes the known actions and molecular mechanisms of pharmacological doses of biotin in animals and current information regarding biotin toxicity.
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