期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 17, 期 11, 页码 939-946出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666170315145410
关键词
Chagas disease; trypanothione reductase; Trypanosoma cruzi; target; drugs; inhibitors
资金
- Comision de Operacion y Fomento de Actividades Academicas (COFAA-Instituto Politecnico Nacional)
- Programa de Estimulos al Desempeno de los Investigadores (EDI-Instituto Politecnico Nacional)
- PRODEP
- School of Veterinary Medicine and Zootechnology of the Universidad Autonoma de Nuevo Leon
Background & Objective: Chagas disease or American trypanosomiasis is a major parasitic disease in Latin America with restricted available treatment: nifurtimox and benznidazole. These two drugs are ineffective in the chronic phase of the disease; therefore, there is a need for the development of new, efficient and safe drugs for the treatment of this pathology. With this goal, one of the promising targets is trypanothione reductase (TR), a key enzyme in the metabolism of Trypanosoma cruzi. Conclusion: In this review, we analyse the importance of TR as a drug target, as well as the well-known and new inhibitors reported in the last decade as potential therapeutic agents for Chagas disease.
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