期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 19, 期 2, 页码 114-124出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666170417170609
关键词
Derivative; mechanism of action; oridonin; pharmaceutical activity; structure modification; structure-activity relationship
资金
- Major Science and Technology Project of Henan Province [161100310100]
- First Affiliated Hospital of Zhengzhou University
Oridonin is one of the major components isolated from Isodon rubescens, a traditional Chinese medicine, and it has been confirmed to exhibit many kinds of biological activities including anticancer, antiinflammation, antibacterial and so on. However, the poor pharmaceutical property limits the clinical applications of oridonin. So many strategies have been explored in the purpose of improving the potencies of oridonin, and structure modification is one thus way. This review outlines the landscape of the recent development of oridonin derivatives with diverse pharmacological activities, mainly focusing on the biological properties, structure-activity relationships, and mechanism of actions.
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