期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 17, 期 15, 页码 1435-1441出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557517666170206151218
关键词
Apoptosis; breast cancer; metastasis; migration; proliferation; ruthenium complexes
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2013/00798-2]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/00798-2] Funding Source: FAPESP
Background: Cancer is one of the main causes of death worldwide. Breast cancer is the most prevalent type of cancer in women and the leading cause of cancer deaths due to its high metastasis to the lymph nodes, lungs bones and brain. Interactions with the stromal microenvironment surrounding tumor cells facilitate tumor cell migration and invasion of tissues and dissemination to other organs, to form metastasis. The development of antitumor metal-based drugs was originated with the discovery of cisplatin, however, its severe side effects represent a limitation for its clinical use. Ruthenium (Ru) complexes with different ligands have been successfully studied as promising antitumor drugs. Conclusion: In this review, we focused on the effects of Ru complexes on breast cancer cells and their impact on different steps of the metastatic process.
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