期刊
BRIEFINGS IN BIOINFORMATICS
卷 20, 期 1, 页码 144-155出版社
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbx093
关键词
ribosome profiling; translational regulation; database; Web server; software
资金
- National Natural Science Foundation of China [31471232]
- Science and Technology Planning Projects of Guangdong Province [2014B030301040]
- Joint Research Fund for Overseas Natural Science of China [3030901001222]
- Center for Precision Medicine
- China Postdoctoral Science Foundation [2015M582459]
Ribosome profiling is emerging as a powerful technique that enables genome-wide investigation of in vivo translation at sub-codon resolution. The increasing application of ribosome profiling in recent years has achieved remarkable progress toward understanding the composition, regulation and mechanism of translation. This benefits from not only the awesome power of ribosome profiling but also an extensive range of computational resources available for ribosome profiling. At present, however, a comprehensive review on these resources is still lacking. Here, we survey the recent computational advances guided by ribosome profiling, with a focus on databases, Web servers and software tools for storing, visualizing and analyzing ribosome profiling data. This review is intended to provide experimental and computational biologists with a reference to make appropriate choices among existing resources for the question at hand.
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