期刊
ELECTROANALYSIS
卷 28, 期 2, 页码 372-379出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201500329
关键词
flutamide; irinotecan; voltammetry; pencil graphite electrode; drug analysis
资金
- Alexander von Humboldt Stiftung, Germany
A sensitive electrochemical method based on square wave cathodic adsorptive stripping voltammetry (SWCASV) using pencil graphite electrodes (PGE) was developed for the individual and simultaneous determination of the anticancer drugs flutamide (Flu) and irinotecan (Irino) in biological fluids. Calibration curves showed an excellent linear response with limits of detection of 1.68 x 10(-9) and 1.55 x 10(-8) M Irino and Flu, respectively. The statistical evaluation of within-day repeatability (n=5) and day to day precision (n=5) showed satisfactory accuracy and precision. SWCASV using a PGE for individual and simultaneous determination of both drugs in bulk form, human urine and serum samples was demonstrated.
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