期刊
BIOMOLECULES
卷 9, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/biom9010001
关键词
microtubule dynamics; mitosis; spindle; molecular motor protein
资金
- NIH [R35 GM122482]
Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.
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