Avoiding the mononuclear phagocyte system using human albumin for mesoporous silica nanoparticle system

The mononuclear phagocytic system is a key participant determining the half-life of nanoparticles (NPs) in the bloodstream and influencing active targeting. Several strategies to extend the circulation time of nanoparticles and to reduce MPS (Mononuclear Phagocyte System) uptake have been developed so far. Here we evaluated the potential of albumin coated-mesoporous silica nanoparticles to overcome MPS clearance in a mouse model of endometrioses. We found that human albumin bath was able to reduce unspecific uptake by liver and spleen but reduced accumulation of NPs to endometriosis site. Our data suggest that although human albumin bath may help to overcome MPS clearance of NPs, it affects NPs uptake by the target site. (C) 2017 Elsevier Inc. All rights reserved.