期刊
MICROCHIMICA ACTA
卷 184, 期 4, 页码 1169-1176出版社
SPRINGER WIEN
DOI: 10.1007/s00604-017-2095-5
关键词
COF-LZU1; Drug analysis; Capillary electrochromatography; In situ synthesis; Amino acids and NSAIDs; Schiff base; Open tubular column
资金
- National Natural Science Foundation of China [81573384, 21375101, 91417301]
- Natural Science Foundation of Hubei Province [2014CFA077]
The covalent organic framework LZU1 (Lan Zhou University-1) is one of the imine-based covalent organic frameworks (COFs) that possesses attractive properties such as structural regularity, stability and good porosity. This work reports on the in-situ synthesis of COF-LZU1 on the inner walls of capillary column for open-tubular capillary electrochromatography (OT-CEC). The fused-silica capillary was first modified with 3-aminopropyltriethoxysilane and glutaraldehyde. Epitaxial growth of COF-LZU1 on the inner walls was accomplished by Schiff base reaction. The formation of COF-LZU1 was confirmed by SEM and FT-IR. The COF-LZU1 coating increases the interactions between analytes and coating, which remarkably improves the CEC separation selectivity of neutral analytes, amino acids and nonsteroidal anti-inflammatory drugs. The COF-LZU1-modified column exhibits good stability and repeatability. The precisions (relative standard deviations) for intra-day, inter-day and column-to column are < 1.6%, 5.6% and 6.8%, respectively. Hence, the imine-based COFs represent attractive stationary phase for application in CEC separations.
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