期刊
CHEMICAL COMMUNICATIONS
卷 55, 期 13, 页码 1939-1942出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc09435g
关键词
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资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB1032 (TP-A5), SFB749 (TP-A4), SPP-1784, CA275/11-1]
- European Research Council (ERC) under the European Union [741912]
- Marie Sklodowska-Curie Individual Fellowship from the European Commission [752420]
- Excellence Cluster CiPSM [EXC117]
- Marie Curie Actions (MSCA) [752420] Funding Source: Marie Curie Actions (MSCA)
Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylenederived alpha,beta-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.
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