期刊
MICROCHIMICA ACTA
卷 184, 期 4, 页码 969-979出版社
SPRINGER WIEN
DOI: 10.1007/s00604-017-2146-y
关键词
Polyaniline; Polypyrrole; Conducting hydrogel; Synergistic materials; Redox species; Immunoprobe nanocomposite; Electrochemical biosensing interface; Immunosensor; Electrochemical assay
资金
- National Natural Science Foundation of China [21273153, 21673143]
- Beijing Natural Science Foundation [2132008]
- Project of the Construction of Scientific Research Base by the Beijing Municipal Education Commission
Conducting polymers possess good conductivity, can be easily modified, have a particular redox activity. Noble metal nanomaterials, in turn, possess high conductivity, catalytic properties and large surface-to-volume ratios. Synergistic materials consisting of both conducting polymer and metal nanomaterial therefore are most useful materials for use in electrochemical immunosensors with improved sensitivity and specificity. This review (with 75 references) gives an overview on advances in conducting polymer based noble metal nanomaterial hybrids for amperometric immunoassay of the 13 most common tumor markers. The review is divided into the following sections: (1) Polyaniline based noble metal nanomaterial hybrids; (2) Polyaniline derivative-based noble metal nanomaterial hybrids; (3) Polypyrrole-based noble metal nanomaterial hybrids. A final section covers future perspectives regarding challenges on the design of electrochemical immunoassays.
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