期刊
MICROCHIMICA ACTA
卷 184, 期 11, 页码 4295-4303出版社
SPRINGER WIEN
DOI: 10.1007/s00604-017-2447-1
关键词
Electrochemistry; Cyclic voltammetry; Differential pulse voltammetry; Electrochemical impedance spectroscopy; Dopamine; Uric acid; Hexacyanoferrrate; Sensor; Carbon-based material; Human serumsamples
资金
- NSF of China [21671049, 21371041, 51572063]
- innovative research team foundation of green chemical technology in the University of Heilongjiang Province, China [2014TD007]
- science and technology innovation foundation of Harbin [2014RFXXJ076]
Vanadium-substituted polyoxometalate clusters of type H8P2Mo16V2O62 and reduced graphene oxide (rGO) were incorporated into a multilayer composite film via combining layer-by-layer self-assembly (using polyethyleneimine) and insitu UV photoreduction. The growth of the multilayer film was monitored by UV-vis spectroscopy. The UV-induced conversion of graphene oxide to rGO in the multilayer film is due to the photocatalytic activity of P2Mo16V2 and was proven by Xray photoelectron spectroscopy. The material was placed on a glassy carbon electrode (GCE) where it displayed good electrocatalytic activity towards oxidation of folic acid (FA) as demonstrated by cyclic voltammetry and differential pulse voltammetry. The modified GCE (best operated at a working voltage of 0.75 V vs Ag/AgCl and a scan rate of 50 mV s(-1)) compared to films containing either P2Mo16V2 or rGO only. The effects of the number of bilayers and of pH values on the electro-oxidation were investigated. The modified GCE was applied to selective determination of FA even in the presence of dopamine (DA) and uric acid (UA) at physiological pH. In fact, the modified GCEmay also be applied to the simultaneous determination of DA, UA and FA. The amperometric response to FA increases linearly in the 10 nM to 0.8 mM FA concentration range, with a 0.28 nM detection limit. The sensor was successfully applied to the determination of FA in spiked human serum samples.
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