期刊
MICROCHIMICA ACTA
卷 184, 期 6, 页码 1573-1585出版社
SPRINGER WIEN
DOI: 10.1007/s00604-017-2219-y
关键词
Electrochemical biosensor; Immunoassay; Signal amplification; Nanocomposites; Myocardial infarction; Cardiac troponin; Nanowires; Nanotubes; Graphenes; Nanoparticles
资金
- National Science Fund of China [21575113, 21605015]
- Specialized Research Fund for the Doctoral Program of Higher Education [20126101110013]
- Natural Science Fund of Shaanxi Province in China [2013KJXX-25]
- Development Project of Science and Technology of Jilin Province [20170101176JC]
- Recruitment Program of Global Youth Experts
- Northeast Normal University
- Scientific Research Foundation of Shaanxi Provincial Key Laboratory [15JS100, 16JS099]
Cardiac troponin (cTn) is a specific and sensitive biomarker for diagnosis of myocardial injury. Hence, numerous kinds of biosensors for cTn have been reported. Electrochemical methods possess inherent advantages over other kinds of sensors because they are specific, sensitive, and simple. By combining the advantages of electrochemical biosensors with those of nanomaterials, some interesting electrochemical biosensor for cTn can be obtained where the nanomaterials trigger substantial signal amplification. This review (with 101 refs.) summarizes the state of the art in electrochemical biosensing of cTn based on the use of nanomaterials. Following an introduction into the field, the use of nanomaterials in electrochemical sensing is briefly discussed. A next section covers strategies for signal amplification by using nanomaterials, with subsections on the use of nanowires, nanotubes, graphenes, and various other nanoparticles. The article concludes with a discussion of the prospects of nanomaterial-based signal amplification and on future research directions.
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