4.2 Article

The emetic activity of staphylococcal enterotoxins, SEK, SEL, SEM, SEN and SEO in a small emetic animal model, the house musk shrew

期刊

MICROBIOLOGY AND IMMUNOLOGY
卷 61, 期 1, 页码 12-16

出版社

WILEY-BLACKWELL
DOI: 10.1111/1348-0421.12460

关键词

emetic animal model; house musk shrew; staphylococcal enterotoxins

资金

  1. JSPS KAKENHI [20580338, 21590475, 23390122]
  2. Japan Science Society
  3. Grants-in-Aid for Scientific Research [16H05030, 16K19119, 21590475, 20580338, 23390122, 16H05185] Funding Source: KAKEN

向作者/读者索取更多资源

Staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus are the most recognizable causative agents of emetic food poisoning in humans. New types of SEs and SE-like (SEl) toxins have been reported. Several epidemiological investigations have shown that the SEs and SEl genes, particularly, SEK, SEL, SEM, SEN and SEO genes, are frequently detected in strains isolated from patients with food poisoning. The purpose of the present study was to evaluate the emetic activity of recently identified SEs using a small emetic animal model, the house musk shrew. The emetic activity of these SEs in house musk shrews was evaluated by intraperitoneal administration and emetic responses, including the number of shrews that vomited, emetic frequency and latency of vomiting were documented. It was found that SEs induce emetic responses in these animals. This is the first time to demonstrate that SEK, SEL, SEM, SEN and SEO possess emetic activity in the house musk shrew.

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