期刊
MICROBIAL DRUG RESISTANCE
卷 23, 期 2, 页码 215-223出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/mdr.2015.0250
关键词
methicillin-resistant Staphylococcus aureus (MRSA); Brazilian-Hungarian clone; SCCmec type III; epidemiology; pulse-field gel electrophoresis; spa
资金
- UTAR Research Fund from Universiti Tunku Abdul Rahman [IPSR/RMC/UTARRF/C2-11/H01]
We investigated the epidemiology and clonality of 175 nonrepetitive methicillin-resistant Staphylococcus aureus (MRSA) isolates from clinical specimens collected between 2011 and 2012 in Kinta Valley in Malaysia. Molecular tools such as polymerase chain reaction, pulsed-field gel electrophoresis, and staphylococcal protein A (spa) typing were used. Our study revealed the predominance of three closely related ermA(+) SCCmec type III pulsotypes belonging to spa type t037 (Brazilian-Hungarian clone), which were deficient in the locus F, but positive for the ccrC gene in majority (65.7%) of the MRSA infections in this region. The first evidence of SCCmec type II MRSA in the country, belonging to spa type t2460, was also noted. Although the carriage of pvl gene was uncommon (8.6%) and mostly confined to either SCCmec type IV or SCCmec type V isolates, most of these isolates belonged to spa types t345 or t657, which are associated with the Bengal-Bay CA-MRSA clone. Interestingly, spa t304 and t690 SCCmec type IV pvl(+) were also detected among the MRSA isolates. Data from this study show the rise of uncommon clones among MRSA isolates in Malaysia.
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