期刊
MICROBES AND INFECTION
卷 19, 期 7-8, 页码 422-431出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2017.05.001
关键词
Aspergillus fumigatus; Lung immune responses; Eosinophils; Gammadelta T cells; Chitin; Caspofungin
资金
- National Institutes of Health [NIH/NIAID R03 R03AI122127]
- Indiana University Biomedical Research Committee
- American Association of Immunologists Careers in Immunology Fellowship
The differential recognition of fungal cell wall polysaccharides that program innate and adaptive immunity to the human opportunistic fungal pathogen Aspergillus fumigatus has been a focus of considerable interest. In a mouse model of fungal conidia aspiration, decreased relative levels of cell wall core carbohydrates beta-1,3-glucan to chitin in A. fumigatus isolates and mutant strains were correlated with increased airway eosinophil recruitment. In addition, an increase in fungal surface chitin exposure induced by the beta-1,3-glucan synthesis-targeting drug caspofungin was associated with increased murine airway eosinophil recruitment after a single challenge of conidia. The response to increased A. fumigatus chitin was associated with increased transcription of IL-17A after a single aspiration, although this cytokine was not required for eosinophil recruitment. Rather, both RAG1 and gamma delta T cells were required, suggesting that this subset of innate-like lymphocytes may be an important regulator of potentially detrimental type 2 immune responses to fungal inhalation and infection. (C) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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