期刊
MICROBES AND INFECTION
卷 19, 期 12, 页码 655-660出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2017.09.008
关键词
H6 subtype avian influenza viruses; Receptor-binding; Respiratory droplet transmission; Guinea pigs
资金
- National Natural Science Foundation of China [31521005]
- National Key RAMP
- D Program of China [2016YFD0500201, 2016YFD0500203]
Binding exclusively to human-type receptors is a prerequisite for avian influenza viruses to transmit from human to human. We previously reported that 34% of H6 avian influenza viruses recognize the human-type receptor, but their affinity for the avian-type receptor remains higher than that for the human-type receptor. Here, we found that a single amino acid change from glutamine to leucine at position 226 of hemagglutinin caused a switch in receptor-binding preference from avian-type to human-type receptors and rendered A/chicken/Guangdong/S1312/2010(H6N2) capable of respiratory droplet transmission in guinea pigs. (C) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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