期刊
MICROBIOLOGY SPECTRUM
卷 7, 期 2, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/microbiolspec.GPP3-0019-2018
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资金
- National Health and Medical Research Council of Australia (NHMRC) [1071659]
- University of Adelaide Beacon Fellowship
The polysaccharide capsule of Streptococcus pneumoniae is the dominant surface structure of the organism and plays a critical role in virulence, principally by interfering with host opsonophagocytic clearance mechanisms. The capsule is the target of current pneumococcal vaccines, but there are 98 currently recognised polysaccharide serotypes and protection is strictly serotype-specific. Widespread use of these vaccines is driving changes in serotype prevalence in both carriage and disease. This chapter summarises current knowledge on the role of the capsule and its regulation in pathogenesis, the mechanisms of capsule synthesis, the genetic basis for serotype differences, and provides insights into how so many structurally distinct capsular serotypes have evolved. Such knowledge will inform ongoing refinement of pneumococcal vaccination strategies.
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