期刊
METABOLISM-CLINICAL AND EXPERIMENTAL
卷 73, 期 -, 页码 36-42出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2017.04.013
关键词
Insulin-like growth factor binding; protein 1; Body composition; Muscle, skeletal; Aged
资金
- Swedish Research Council
- Swedish Frimurarorden
- Family Erling-Perssons Foundation
- Forskningsradet om Halsa Arbetsliv och Valfard
- ALF-Uppsala County Council
- European Union's Horizon research and innovation program [633589]
Objective. Skeletal muscles serve several important roles in maintaining good health. Insulin like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. In the present study we investigate the association between serum IGFBP-1 and muscle mass. Design. Cross-sectional analysis of 4908 women, between 55 and 85 years old, participating in the Swedish Mammography Cohort-Clinical. Methods. We defined low relative muscle mass (LRMM) as an appendicular lean mass divided by height squared of less than 5.45 (kg/m(2)), assessed by dual energy x-ray absorptiometry. IGFBP-1 was measured by radioimmunoassay. Logistic regression was used to calculate odds-ratios of LRMM across quartiles of IGFBP-1. Results. The odds of LRMM increased across quartiles of IGFBP-1. In the age-adjusted model the odds-ratio (OR) of LRMM was 3.41 (95% CI: 2.55-4.56), comparing the highest to the lowest quartile. This estimate was attenuated in multivariate models (OR: 1.84, 95% CI: 1.34-2.53), mainly due to inclusion of fat mass index. Conclusion. Women with higher IGFBP-1 were more likely to have a low relative muscle mass. High IGFBP-1 may be a marker of a catabolic state. (C) 2017 Elsevier Inc. All rights reserved.
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