期刊
NATURE REVIEWS IMMUNOLOGY
卷 19, 期 3, 页码 170-183出版社
NATURE PORTFOLIO
DOI: 10.1038/s41577-018-0095-2
关键词
-
类别
资金
- Wellcome Trust [104549/Z/14/Z, 103830/Z/14/Z]
- Wellcome Trust [103830/Z/14/Z, 104549/Z/14/Z] Funding Source: Wellcome Trust
Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation of substrates and organelles and participation in cell survival decisions. We review here the crucial functions of autophagy in controlling the differentiation and homeostasis of multiple immune cell types and discuss the potential mechanisms involved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据