期刊
METABOLIC SYNDROME AND RELATED DISORDERS
卷 15, 期 5, 页码 213-219出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/met.2017.0003
关键词
metabolic syndrome; cardiovascular risk; vitamin D deficiency
资金
- Deanship of Research/Jordan University of Science and Technology [20150266]
Background: Metabolic syndrome (MetS) identifies subjects with increased risk of cardiovascular disease when they have a combination of insulin resistance, obesity, hypertension, hyperglycemia, low high-density lipoprotein cholesterol (HDL-C), and elevated triglycerides (TGs). Increasing evidence suggests that vitamin D deficiency could be associated with diabetes and MetS. The aim is to assess if 25-hydroxyvitamin D (25-OHD) is correlated with cardiovascular risk components of MetS. Methods: A cross-sectional study involved 124 diabetic patients with MetS according to International Diabetes Federation definition. 25-OHD was measured using liquid chromatography-tandem mass spectrometry (LCMS/MS). Fasting insulin, lipid profile, glucose, and hemoglobin-A1c (HbA1c) were determined using routinely standard laboratory methods. Insulin resistance was assessed using homeostatic model assessment (HOMA). Results: 59.68% and 27.42% of patients have vitamin D deficiency and insufficiency, respectively. Systolic blood pressure (SBP) was significantly higher in patients with vitamin D deficiency compared to patients with sufficient vitamin D (P < 0.05). Serum log (25-OHD) was inversely correlated with SBP, HbA1c, low-density lipoprotein cholesterol (LDL-C), TGs, and total cholesterol and directly correlated with pancreatic b cell function (HOMA-b) (P < 0.05). Multiple linear regression analysis has shown that SBP can be predicted from log (25-OHD) (B=-9.388, P < 0.05), while HbA1c, LDL-C, TGs, total cholesterol, and HOMA-b cannot be predicted from log (25-OHD), (P > 0.05). Conclusions: Vitamin D deficiency was very prevalent among patients with MetS. 25-OHD was inversely correlated with glycemic control and cardiovascular risk components of MetS except HDL-C, insulin resistance, and obesity. SBP was the only cardiovascular risk component that can be predicted from vitamin D concentrations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据