期刊
NON-CODING RNA
卷 5, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ncrna5010018
关键词
tRNA-derived small RNAs; tsRNAs; translational regulation; stress response; Argonaute
资金
- Ministry of Science and Technology of the People's Republic of China [2016YFA0500800]
- National Natural Science Foundation of China [91731301, 31571333, 91431101]
- Peking-Tsinghua Center for Life Science
Transfer RNA-derived small RNAs (tsRNAs) are an emerging class of regulatory non-coding RNAs that play important roles in post-transcriptional regulation across a variety of biological processes. Here, we review the recent advances in tsRNA biogenesis and regulatory functions from the perspectives of functional and evolutionary genomics, with a focus on the tsRNA biology ofDrosophila. We first summarize our current understanding of the biogenesis mechanisms of different categories of tsRNAs that are generated under physiological or stressed conditions. Next, we review the conservation patterns of tsRNAs in all domains of life, with an emphasis on the conservation of tsRNAs between twoDrosophilaspecies. Then, we elaborate the currently known regulatory functions of tsRNAs in mRNA translation that are independent of, or dependent on, Argonaute (AGO) proteins. We also highlight some issues related to the fundamental biology of tsRNAs that deserve further study.
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