期刊
METABOLIC BRAIN DISEASE
卷 33, 期 1, 页码 251-259出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-017-0154-6
关键词
Alzheimer's disease; Amyloid beta-peptide (A beta); Nootkatone; Oxidative stress; Acetylcholin esterase (AChE); Neuroprotective effect
资金
- National Natural Science Foundation of China [81573580, 81503229]
- Foundation of Liaoning Education Committee [51120427]
- Doctoral Starting up Foundation of Liaoning Science and Technology Department [51120390]
- Key Laboratory of Polysaccharide Bioactivity Evaluation of TCM of Liaoning Province
- Key Laboratory of Quality Control of TCM of Liaoning Province [17-137-1-00]
The sesquiterpene nootkatone (NKT), isolated from Alpiniae oxyphyllae Fructus, was shown to possess protective effects on neurons. In our study, by using an Alzheimer's disease (AD) model of mice induced by intracerebroventricular (i.c.v.) injection of A beta(1-42) oligomers, we investigated the effects of NKT on memory impairment and further evaluated the pathological changes of mice. AD mice were treated by i.c.v. injection of NKT (at a dose of 0.02 mg/kg and 0.20 mg/kg) or vehicle (PBS) into the lateral ventricle once daily for 5 consecutive days. The behavioral tasks were performed, and levels of some biochemical indicators and histopathological changes of the brain were evaluated to elucidate the mechanism of NKT in the treatment of AD. The results revealed that NKT significantly improved the neurobehavioral performance of the AD mice in the Y-maze and Morris water maze tests. More importantly, NKT treatment decreased the malondialdehyde (MDA), A beta as well as the acetylcholin esterase (AChE) levels in the mice brain, while increased the glutathione peroxidase (GSH-Px) levels with improved histopathological changes in the hippocampus. These findings provided evidences for the beneficial role of NKT in A beta(1-42)-induced mice AD model linking to anti-oxidative and anti-AChE activities with inhibitory effect against A beta accumulation.
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