期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 8, 页码 2182-2186出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9ob00110g
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资金
- Special Funds for Economic Development of Marine Economy of Guangdong Province [GDME-2018C010]
- National Natural Science Foundation of China [81741154, 81741158, 21772210, 41776169]
- Institution of South China Sea Ecology and Environmental Engineering, CAS [ISEE2018PY04]
- Pearl River S&T Nova Program of Guangzhou [201610010017]
Versispiroketal A (1), an unprecedented 6/5/5/6 tetracyclic polyketide featuring a rarely encountered bridge-fused spiroketal skeleton, was isolated from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. The structure and absolute configuration of 1 were unequivocally determined by comprehensive spectroscopic analysis, single-crystal X-ray diffraction analysis and quantum chemical ECD calculations. Compound 1 showed weak cytotoxicity against four cancer cell lines. A plausible biosynthetic pathway for 1 was also postulated.
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