期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 112, 期 2, 页码 81-93出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-02760160373
关键词
microbiome; paratransgenesis; mosquito; arbovirus; vector control; malaria
资金
- NIH [R21AI124452, 2T32AI007526]
- University of Texas Rising Star award
Arthropods harbor a diverse array of microbes that profoundly influence many aspects of host biology, including vector competence. Additionally, symbionts can be engineered to produce molecules that inhibit pathogens. Due to their intimate association with the host, microbes have developed strategies that facilitate their transmission, either horizontally or vertically, to conspecifics. These attributes make microbes attractive agents for applied strategies to control arthropod-borne disease. Here we discuss the recent advances in microbial control approaches to reduce the burden of pathogens such as Zika, Dengue and Chikungunya viruses, and Trypanosome and Plasmodium parasites. We also highlight where further investigation is warranted.
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