期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 112, 期 11, 页码 733-740出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/0074-02760170109
关键词
cytotoxicity; CD8+T cells; NK cells; cutaneous leishmaniasis; immunopathology
资金
- National Institutes of Health [U01 AI088650-06]
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-gamma and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
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