期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 7, 页码 1773-1777出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02463d
关键词
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资金
- National Research Foundation of Korea (NRF) [NRF-2016R1A2B4015351, NRF-2016R1A4A1011451]
- Government of Korea
- Kyung Hee University [KHU-20181169]
An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using N-aromatic zwitterions, aldehydes, and amino acids. The developed reactions proceed through azomethine ylides generated in situ from the decarboxylated reactions of aldehydes and amino acids followed by the [3 + 2] cycloaddition of N-aromatic zwitterions under mild reaction conditions.
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